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We assessed the functional impact of the epistasis signals across a range of functional/-omics datasets identifying significant single-variant eQTLs across brain tissues,。

Epistasis occurs when the phenotype expression of one gene is influenced by another gene. Example: Gene A must be present for Gene B to express a certain trait. Example: The coat color in mice is a classic example。

Epistasis is the interaction between two non-allelic genes where the phenotypic expression of one gene is masked or suppressed by the expression of one or more other genes. Earlier, Mendelian and his coworkers。

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